allergy science definition

An abnormally high immunologic sensitivity to certain stimuli such as drugs, foods, environmental irritants, microorganisms, or physical conditions, such as temperature extremes. These stimuli act as antigens, provoking an immunological response involving the release of inflammatory substances, such as histamine, in the body. Allergies may be innate or acquired in genetically predisposed individuals. Common symptoms include sneezing, itching, and skin rashes, though in some individuals symptoms can be severe. See also anaphylactic shock.